Erythropoietin in Brain Development and Beyond
نویسندگان
چکیده
منابع مشابه
Erythropoietin in Brain Development and Beyond
Erythropoietin is known as the requisite cytokine for red blood cell production. Its receptor, expressed at a high level on erythroid progenitor/precursor cells, is also found on endothelial, neural, and other cell types. Erythropoietin and erythropoietin receptor expression in the developing and adult brain suggest their possible involvement in neurodevelopment and neuroprotection. During isch...
متن کاملRecognition and characterization of Erythropoietin binding-proteins in the brain of mice
Objective(s): Erythropoietin (EPO), is a 34KDa glycoprotein hormone, which belongs to type 1 cytokine superfamily. EPO involves in erythrocyte maturation through inhibition of apoptosis in erythroid cells. Besides its main function, protective effects of EPO in heart and brain tissues have been reported. EPO has a critical role in development, growth, and homeostasis of brain. Furthermore EPO h...
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متن کاملErythropoietin receptor signalling is required for normal brain development.
Erythropoietin, known for its role in erythroid differentiation, has been shown to be neuroprotective during brain ischaemia in adult animal models. Although high levels of erythropoietin receptor are produced in embryonic brain, the role of erythropoietin during brain development is uncertain. We now provide evidence that erythropoietin acts to stimulate neural progenitor cells and to prevent ...
متن کاملErythropoietin and the hypoxic brain
It has been almost a century since Carnot and Deflandre postulated that a humoral factor regulates red blood cell production (Carnot and Deflandre, 1906b). The history of the discovery and characterisation of this factor – later termed erythropoietin (EPO) – has recently been reviewed by Fisher (2003). To fulfil its principal function, i.e. the regulation of red cell production, EPO binds to a ...
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ژورنال
عنوان ژورنال: Anatomy Research International
سال: 2012
ISSN: 2090-2743,2090-2751
DOI: 10.1155/2012/953264